2/3
38 children were divided into two groups:
Group I received daily hGH injections
Group II received alternate day hGH injections
It is important to note that the
total weekly dosage of hGH was the same for both groups. Both groups received the hGH therapy contiguously for two years. Their natural growth was followed for an additional two years after hGH therapy ended.
They were all measured at three-month intervals during the four-year period—two years with hGH therapy and two years thereafter. Serum GH was measured by double antibody RIA kit.
During hGH therapy, both groups accelerated their growth substantially:
Group I receiving the daily hGH injections first and second year velocity was 3.4 and 2.3 SD.
Group II receiving the alternate hGH inj. had 3.0 and 2.0 SD for first and second year, respectively.
Over the initial six months after withdrawal of therapy, growth velocity decelerated to a low nadir –3.9 SD score for the daily therapy group, whereas it decelerated in the alternate day group to only –0.2 SD score.
During the 2 years off therapy, the latter group taking EOD injections maintained growth rates of –0.2 to –1.2 SD score, which is similar to their SD score prior to the hGH treatment. The daily group also recovered but very slowly, on the fourth semiannual evaluation off therapy. The cumulative 4-year growth velocity—2 yrs on and 2 yrs off therapy—of the alternate day group was greater than that of the daily therapy group: mean, 0.9 vs. 0.3 SD score.
At the end of the 4-yr therapy period, the adult height prediction of the alternate day group was greater than that of the daily group by a mean of 6.5 cm—which is over 2.5*"* in height.
In even simpler English, to translate what it may mean to us is that using hGH everyday will only negligibly give better short-term results. Yet using
alternate day hGH will give radically
better long-term results and
much better recovery. As the body may get back to homeostasis much faster.
The two groups got the same weekly total hGH dosage, so every other day hGH injections would be twice as many IU as if you used it every day. The researchers said the dose was of less importance than the schedule of the injections. Daily hGH therapy for 3 years caused subnormal growth persisting for 1.5 years (
very bad).
It may be that the problem is not related to the levels of hGH or IGF-1 secretion but rather the body's decreased sensitivity to it. The interesting part is that the serum GH levels and serum IGF-I and IGF-binding protein remained unaffected, or relatively mutely affected.
Your body's endogenous secretion of GH resumes within days, even after long-term hGH therapy.
The researcher’s hypothesis is that the tolerance may be in the “GH signal transduction in selective target organs in response to the disappearance of the unique pulsatile pattern of serum GH during GH therapy. This is due to the fact that GH taken via SubQ injections does not match your body's own GH release schedule."
Daily SubQ administration of GH results in an unphysiological serum GH profile, with peak levels at 4h and a slow decline over the course of the following 12–24 h. This pattern can be regarded as continuous administration, rather than the body's natural physiological GH pulses with a frequency of about eight pulses per day.
Assuming that the withdrawal syndrome is related to tolerance that might have developed toward hGH or IGF-I, we tried to prevent it by alternate day treatment. Moreover, hGH doses used in therapy often stimulate IGF-I to supraphysiological serum levels, suggesting that target tissues IGF-I may also be higher than normal. The mechanism seems, therefore, to rest with hGH and IGF-I action at their target tissues. We now show that alternate day therapy with hGH in children with an intact GH-IGF-I axis prevents the withdrawal syndrome.”
Researchers link the analogy to another endocrine tolerance and withdrawal syndrome: “alternate day therapy with glucocorticosteroids prevents tolerance to that hormone to a substantial degree. Interestingly, glucocorticoid withdrawal syndrome can also occur while the hypothalamic-pituitary-adrenal axis is intact, indicating that tolerance to glucocorticoids has developed at the target organ level.”
An example of a good protocol could be:
hGH taken for 16 weeks or more at 8 IU every other day, split to 4 IU fasted immediately after waking and another 4 IU taken eight hours later. This approach is quite conservative, and may be optimal. The dose may be further split if desired to reduce the total IU injected at any one point in time.
Obviously, you may extend past four months, and take more IU per day. This approach goes with 8 IU EOD, so it is equivalent to those who would otherwise go with 4 IU ED, which is what most do. There is some controversy as to how many of these IU the body can utilize at once. There are many opinions and doctrines in endocrinology, bodybuilding, etc. Older individuals on hGH for life would not mind, as no rebound would affect them. Professional bodybuilders probably wouldn't mind as well.
This study targeted
height in adolescents—not
lean body mass in adult bodybuilders, or
antiaging effects in middle-aged adults—so it's still a matter of extrapolation as to whether or not the results can be applied to these user subgroups. Bodybuilders aren't children, nor idiopathic hGH deficient and not aGHD.
Since the weekly dosages remain the same, as well as the duration of the hGH usage, just changing to the EOD protocol from the previous standard everyday injection protocol is worth it, and seems statistically a better bet than the everyday protocol.
TL;DR: Alternate day hGH therapy prevents tolerance and yields improved long-term results with the same weekly total IU administration.
Another post of his;
Anything over ~
1.5–
2.0 IU is best split into multiple injections, as that's viewed as the max that can be dosed without sides, and properly put to use at any given point in time.
A
preliminary dosing schedule is outlined on the hGH Compound Description page in the Wiki. Another study is described in the wiki that incorporates similar findings of improved results seen via
every-other-day dosing, in this instance, in small children ranging in ages from two to four.
CREDIT TO /u/DecaTest - ADMIN ON Reddit.com/r/steroids.