@Sorbate what is considered a high dose? 6iu to 9iu? Also, is long term anything over 6 months or 1 year or 2+ years? I’m gonna do some digging on this. Thanks for mentioning it.
I have no scientific evidence, but logic would say, any amount that starts to cause insulin resistance over a specific point over a specific duration.
Each person is likely a bit different.
As an example, 3 iu for a year may cause beta cell stress, done for 5 years could create an issues of reduced beta cell production. (Could occur in less time)
My thought is, the beta cells can likely take a bit of a pounding, like the liver and kidneys (obviously more of a pounding in a younger person) for a certain amount of time before damage starts to occur. So for me it could be 6 months, for you could be 2 years since you are younger.
I would bet that close to a replacement dose wouldn’t cause any issues, so 1 iu, 1.5 iu long term. But taking a few months off every year.
Just like running 125-200 mg of test long term wouldn’t cause issues.
Now if Dave Pulmbo is correct that using long acting insulin gives the beta cells a rest, and helps with recovery, then as long as you don’t extremely abuse like 5iu for a couple years, then you might be able to reverse the damage.
Just like I took NAC and astragulus to revert what I suspect very minor damage to my kidneys (thru minor inconsistent protein leakage) I suspect I got from running tren and other compounds at higher than trt for numerous years.
That being said, is this a complete cure to both the beta cells or kidneys, likely not, but will bring it within clinical ok levels as long as you don’t continually stress the organs. The main reason why I am not running tren or high doses anymore.
This is also why I like the idea of pulsing gh peptides better, because you are still allowing your body some control thru the feed back loops.
That being said, I could be completely wrong in my thought process on everything, but using the basic knowledge I have and applying it in a simple way for me to understand just seems to make complete sense.