With Tbol you may not not, though some might (everyone acts different), but for the more harsher orals you definitely will. Myself, at my age I'd probably need it with Tbol or even Anavar.At this point I don’t think it’s worth the hassle if I’m running moderate doses of Tbol/var for 6 weeks.
I still run NAC, milk thistle, C-Liver, vitamin C amongst other supplements
On a side note, I know CMS has Tudca, and they're in Canada. However, they change brands every now and then, so I can't comment on how good their's is.