I have been delving into this topic mostly because I like Primo so much and my total test on TRT is in the high end of the norm but even 50-100 mg of Primo a week (over an extended period) will increase my free testosterone 3-4 times the top of the range. Is this good, bad or ugly?
I love Primo, it makes me feel good, small incremental increases in muscle mass/strength you tend to keep, and a boost in libido. All good while only helping my blood markers like lymphocyte count by a small margin while all others are not impacted (minus the hormones).
Total test is the total amount of test available in the blood but often doctors don't look at free test and only look at total test which makes it very easy to get a TRT script. That is how I got my first TRT script - no LH, no SHBG, no estrogen - just total test, tested twice.
What I find interesting and have read a few times is, "The possibility of excessive bondage means that it is possible to have normal levels of total testosterone but still have insufficient free testosterone to perform its essential functions. Too little free testosterone can lead to poor muscle development, irritability, lowered sex drive and a host of other issues that one may not readily associate with too little free testosterone." So how important is free test for sex drive and muscular development?
This post is meant as a discussion. Further, just info I have read and discussed with others.
Until recently, free testosterone was the only type considered biologically active. It turns out, however, that the portion of the hormone bound to serum albumin tends to become available in the capillary bed. Therefore, non-SHBG-bound testosterone is also deemed as “bioavailable.”
One way of looking at bioavailable testosterone is that it is like a reserve supply, ready for use when the body is low on free testosterone. However, scientists still don’t know how much bioavailable testosterone goes on to be absorbed by cells in these conditions.
Further - copy and paste:
Total testosterone levels have been the main indicator of a man’s health and fertility for many years.
Now, as doctors are starting to learn more about free testosterone, it is becoming apparent that the true indicators of a man’s strength and virility include both bound and unbound fractions of this hormone.
What does this all mean? Suppose that you feel symptoms of low testosterone levels, such as:
Then, suppose that you took a testosterone test that only accounted for the grand total testosterone levels – and it shows that you have normal total testosterone levels.
Without taking into account your free testosterone levels, your doctor may wrongly attribute these symptoms to another condition and prescribe treatment plans for said condition.
While in fact, the problem may lie in the insufficient amount of free testosterone circulating your body.
Since free testosterone is important since it helps in cell replication and bone and muscle strength, it plays a vital role in a man’s body.
If you worry about worsening sexual health, consulting your doctor to gain normal testosterone levels is recommended."
My GP and Endo who put me on TRT before both tested Total test and nothing else, I also believe most GP's don't know much about hormones but endo's?
Regardless of what I read and delve into the topic further, I will always lower my TRT dosage and add in a little Primo to have a lower total test and a higher free test number for the mental, physical, and sexual impacts. There is a lot of chatter about Primo (DHT compounds) driving down your estrogen but I have never experienced this once. I am sure it happens but not with me. It has zero impact up to 300 mg per week on my estrogen numbers. Luckily, NPP/Deca/or any test ester and DHT drug has zero impact on my estrogen. It is always right in the middle of the range as is my prolactin. Keep in mind a blast is 150 mg of test E, 100-150 mg of Primo or NPP, 2 IU of script HGH and maybe some 1 ML of Iona-Gen per day.
I am very interested in some of the experiences and big brains on this forum. Nothing will change my mind about a high free test number based on how I feel when it is higher but I am curious other's opinion on mood, sex drive, muscle building increases, etc.
thanks,
GR
I love Primo, it makes me feel good, small incremental increases in muscle mass/strength you tend to keep, and a boost in libido. All good while only helping my blood markers like lymphocyte count by a small margin while all others are not impacted (minus the hormones).
Total test is the total amount of test available in the blood but often doctors don't look at free test and only look at total test which makes it very easy to get a TRT script. That is how I got my first TRT script - no LH, no SHBG, no estrogen - just total test, tested twice.
What I find interesting and have read a few times is, "The possibility of excessive bondage means that it is possible to have normal levels of total testosterone but still have insufficient free testosterone to perform its essential functions. Too little free testosterone can lead to poor muscle development, irritability, lowered sex drive and a host of other issues that one may not readily associate with too little free testosterone." So how important is free test for sex drive and muscular development?
This post is meant as a discussion. Further, just info I have read and discussed with others.
Bioavailable Testosterone
Until recently, free testosterone was the only type considered biologically active. It turns out, however, that the portion of the hormone bound to serum albumin tends to become available in the capillary bed. Therefore, non-SHBG-bound testosterone is also deemed as “bioavailable.”
One way of looking at bioavailable testosterone is that it is like a reserve supply, ready for use when the body is low on free testosterone. However, scientists still don’t know how much bioavailable testosterone goes on to be absorbed by cells in these conditions.
Further - copy and paste:
"How Does Free vs Total Testosterone Affect Male Health?
Total testosterone levels have been the main indicator of a man’s health and fertility for many years.
Now, as doctors are starting to learn more about free testosterone, it is becoming apparent that the true indicators of a man’s strength and virility include both bound and unbound fractions of this hormone.
What does this all mean? Suppose that you feel symptoms of low testosterone levels, such as:
- Poor muscle development
- Increased irritability
- Lowered sex drive
Then, suppose that you took a testosterone test that only accounted for the grand total testosterone levels – and it shows that you have normal total testosterone levels.
Without taking into account your free testosterone levels, your doctor may wrongly attribute these symptoms to another condition and prescribe treatment plans for said condition.
While in fact, the problem may lie in the insufficient amount of free testosterone circulating your body.
Since free testosterone is important since it helps in cell replication and bone and muscle strength, it plays a vital role in a man’s body.
If you worry about worsening sexual health, consulting your doctor to gain normal testosterone levels is recommended."
My GP and Endo who put me on TRT before both tested Total test and nothing else, I also believe most GP's don't know much about hormones but endo's?
Regardless of what I read and delve into the topic further, I will always lower my TRT dosage and add in a little Primo to have a lower total test and a higher free test number for the mental, physical, and sexual impacts. There is a lot of chatter about Primo (DHT compounds) driving down your estrogen but I have never experienced this once. I am sure it happens but not with me. It has zero impact up to 300 mg per week on my estrogen numbers. Luckily, NPP/Deca/or any test ester and DHT drug has zero impact on my estrogen. It is always right in the middle of the range as is my prolactin. Keep in mind a blast is 150 mg of test E, 100-150 mg of Primo or NPP, 2 IU of script HGH and maybe some 1 ML of Iona-Gen per day.
I am very interested in some of the experiences and big brains on this forum. Nothing will change my mind about a high free test number based on how I feel when it is higher but I am curious other's opinion on mood, sex drive, muscle building increases, etc.
thanks,
GR