Retatrutide, tirzepatide, or semaglutide

Winstrolv

Winstrolv

Member
What’s up boys and girls,
Running TRT+ right now
Test Prop 140 mg/wk + Primo 150 mg/wk (270 ish total).

Looking at adding Tirzepatide or Retatrutide, but I’m cautious because I had a brutal reaction to Semaglutide.
Ran sema for 3–4 weeks, 0.75 mg/wk split 3x. Tolerance was trash.
Severe nausea/vomiting, dizziness, GI shutdown (couldn’t shit at all), nasty sulfur burps. Ended up in the ER from non-stop vomiting like for fucking hours + dehydration. Docs straight up said its because of sema, so I pulled it.
Can’t deny the efficacy though dropped around 12-14 lbs in under 4 weeks.
Currently sitting around ~14-15% BF by last measurements. Not fat, not peeled. Winter always makes me hold a bit, and I’m planning a long, controlled winter cut, not a crash.
Given how hard sema wrecked me, I’m not eager to blindly jump into another GLP unless there’s a real upside.
Looking for input from guys who’ve run Tirz or Reta after getting wrecked on sema better tolerance, dosing strategies, worth it or not

Thanks!
 
tirz is stronger in the glp so it will suppress appetite better then reta but i found the sides were worse on tirz. It was tolerable but they were there so given your reaction to sema, tirz might be similar.
Reta i found to be much easier. There stomach issues were not an issue and i had more energy but the appetite suppression was not the same.
Keep in mind that some people should not use these at all due to stomach issues.
There is a list of things you should be doing while on any of these compounds to keep things moving.
Youtube is you friend
 
I will say that when i used tirz, my wife and my buddy and his wife were also using the same stuff. All first time users.
I was the only one that had massive constipation and some fatigue. But i am also the only one that eats like a bodybuilder.
Tirz and sema can easily make people skinny fat. Reta is better in this regard
 
Sometrtdude said:
Hands down Reta. Start at .5mg one time per week….titrate up to no more than 4mg. Only pin once a week. With Reta you can still eat what you need to for the most part and not get near as sick.
Click to expand...
Agree with this...

I'm trying Reta again at lower dose and it's going fine. Sometimes a little rot gut at night, but tolerable.
 
Thanks for all the answers, guys, I really appreciate it.

Sometrtdude said:
Hands down Reta. Start at .5mg one time per week….titrate up to no more than 4mg. Only pin once a week. With Reta you can still eat what you need to for the most part and not get near as sick.
Click to expand...
How long did you run Reta for?
Was it actually super effective, or did it mainly just help you control food noise and appetite?
 
Winstrolv said:
Thanks for all the answers, guys, I really appreciate it.


How long did you run Reta for?
Was it actually super effective, or did it mainly just help you control food noise and appetite?
Click to expand...
I’m coming up on 4 months…. at 2mg a week just to take care of noise mainly. Helps me stay focused on high quality food intake. Curbed my appetite but Reta won’t typically punish you for eating unless is greasy or fatty foods
 
Sometrtdude said:
Hands down Reta. Start at .5mg one time per week….titrate up to no more than 4mg. Only pin once a week. With Reta you can still eat what you need to for the most part and not get near as sick.
Click to expand...
I dont fully understand the reta can only be once a week, have been pinning daily with insane results
 
Reta without a doubt. I’m seeing amazing results from 1mg every 5 days. I recommend staying a low dose for a month before titrating up
 
Z155 said:
I dont fully understand the reta can only be once a week, have been pinning daily with insane results
Click to expand...
Half life is around 7 days. You can pin everyday if you want to but just not necessary. More stable levels? Ya probably…..but marginal at best compared to 1 per week
 
Why do you even need it?
Is it really worth the risk after having such a terrible time with semaglutide?
 
Using Reta now more out of curiosity than anything else. Got some mild diarrhea but definitely the sulphur burps.

Weight has come off a bit but I’m keeping dose fairly low at 7.5 mg per week over 2 injections.

Found sides were a bit worse with once a week injections.
 
Morning @The Old Guy - I have never looked into any of these based on the few who had sides, they were bad and many ended in the ER or ICU (of course like all drugs, that is the minority). I know you used @Funnyman and not sitting on a high horse, but I don't understand (asking for opinion/advice) why people force more food and take reta? They eat more food for repair and to build muscle, PED's to build/retain muscle, but Reta is known to blunt appetite and slow gastric emptying. If you are hammering food (not you / you didn't mention it) are you not creating a recipe for colon damage? If you ever want to scare the shit out of yourself - pardon the pun, check pics of people on chronic opioid drugs who are not regular but eat normal. Take some of the men/women who eat 2 or more times what a normal man would eat, it appears to be a recipe for disaster. I am asking - not stating any facts, just an observation thinking about it.
Maybe better glucose uptake/increase energy expenditure counteracts this?
I know you are a big guy but above people talk about .5 mg a week and I have heard of many using 1 mg twice a week or 1 mg a week. You are taking 7.5 mg and called it a low dose, I know Eli Lilly is putting it through the phases but I have not found much on dosages other than websites, mentioning stating at 1 mg and every 4 weeks and then going to 2, 4, 6 and up to 12 max.
Curious @Jussik, @BanditNOLIMIT, @storman, or any member - I assume this is not a forever drug - when you stop if you don't adjust, does the fat come back. I'm basing this on the fact fat cells generally do not disappear, they just shrink - hence the yoyo effect on specific PED's (getting bigger/smaller), curious if this is the same with Reta?
None of these comments are me making statement as I don't know - this is more of a question post for those who have not used it?
Thank you
 
Not sure if you have seen the actual study on Retatrutide:


Summary:
We enrolled 338 adults, 51.8% of whom were men. The least-squares mean percentage change in body weight at 24 weeks in the retatrutide groups was −7.2% in the 1-mg group, −12.9% in the combined 4-mg group, −17.3% in the combined 8-mg group, and −17.5% in the 12-mg group, as compared with −1.6% in the placebo group.

Thats a double-blind, randomized, placebo-controlled trial.

So it works 100%
 
Goldenrod said:
Morning @The Old Guy - I have never looked into any of these based on the few who had sides, they were bad and many ended in the ER or ICU (of course like all drugs, that is the minority). I know you used @Funnyman and not sitting on a high horse, but I don't understand (asking for opinion/advice) why people force more food and take reta? They eat more food for repair and to build muscle, PED's to build/retain muscle, but Reta is known to blunt appetite and slow gastric emptying. If you are hammering food (not you / you didn't mention it) are you not creating a recipe for colon damage? If you ever want to scare the shit out of yourself - pardon the pun, check pics of people on chronic opioid drugs who are not regular but eat normal. Take some of the men/women who eat 2 or more times what a normal man would eat, it appears to be a recipe for disaster. I am asking - not stating any facts, just an observation thinking about it.
Maybe better glucose uptake/increase energy expenditure counteracts this?
I know you are a big guy but above people talk about .5 mg a week and I have heard of many using 1 mg twice a week or 1 mg a week. You are taking 7.5 mg and called it a low dose, I know Eli Lilly is putting it through the phases but I have not found much on dosages other than websites, mentioning stating at 1 mg and every 4 weeks and then going to 2, 4, 6 and up to 12 max.
Curious @Jussik, @BanditNOLIMIT, @storman, or any member - I assume this is not a forever drug - when you stop if you don't adjust, does the fat come back. I'm basing this on the fact fat cells generally do not disappear, they just shrink - hence the yoyo effect on specific PED's (getting bigger/smaller), curious if this is the same with Reta?
None of these comments are me making statement as I don't know - this is more of a question post for those who have not used it?
Thank you
Click to expand...
I think the problem with people taking these drugs is that they use it as a band aid for a bad relationship with food. If you're taking a drug that suppresses your appetite and then you stop it and go back to your old eating habits.... you will 100% gain back your fat. If you have a healthy relationship with food and you keep the same habits you have while taking these drugs, you will not gain back the fat once you stop the drug. At the end of the day, whether you're on reta/tirz/sem, it's still calories in vs. calories out.
 
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Goldenrod said:
Morning @The Old Guy - I have never looked into any of these based on the few who had sides, they were bad and many ended in the ER or ICU (of course like all drugs, that is the minority). I know you used @Funnyman and not sitting on a high horse, but I don't understand (asking for opinion/advice) why people force more food and take reta? They eat more food for repair and to build muscle, PED's to build/retain muscle, but Reta is known to blunt appetite and slow gastric emptying. If you are hammering food (not you / you didn't mention it) are you not creating a recipe for colon damage? If you ever want to scare the shit out of yourself - pardon the pun, check pics of people on chronic opioid drugs who are not regular but eat normal. Take some of the men/women who eat 2 or more times what a normal man would eat, it appears to be a recipe for disaster. I am asking - not stating any facts, just an observation thinking about it.
Maybe better glucose uptake/increase energy expenditure counteracts this?
I know you are a big guy but above people talk about .5 mg a week and I have heard of many using 1 mg twice a week or 1 mg a week. You are taking 7.5 mg and called it a low dose, I know Eli Lilly is putting it through the phases but I have not found much on dosages other than websites, mentioning stating at 1 mg and every 4 weeks and then going to 2, 4, 6 and up to 12 max.
Curious @Jussik, @BanditNOLIMIT, @storman, or any member - I assume this is not a forever drug - when you stop if you don't adjust, does the fat come back. I'm basing this on the fact fat cells generally do not disappear, they just shrink - hence the yoyo effect on specific PED's (getting bigger/smaller), curious if this is the same with Reta?
None of these comments are me making statement as I don't know - this is more of a question post for those who have not used it?
Thank you
Click to expand...
I use/used it as a tool on a cut for my vacation. Im off it now and im also off my cal deficit diet so yes, the fat came back lol
This was to be expected for me tho as it was always just being used as a tool for a cutting cycle. Had no intentions of running this year round.
I may try some reta after the new year with a cal surplus just to see what happens
 
My wife came off tirz the same time i came off reta. She is only a 1lb up with no real signs of it climbing higher. She is not "bulking" like me tho
 
What i miss the most is the increased insulin sensitivity. I just did not bloat up while on it, even after eating too much shit.
Now im back to walking the carb tight rope. Been on that fucking rope for over 25 years
 
Goldenrod said:
Curious @Jussik, @BanditNOLIMIT, @storman, or any member - I assume this is not a forever drug - when you stop if you don't adjust, does the fat come back. I'm basing this on the fact fat cells generally do not disappear, they just shrink - hence the yoyo effect on specific PED's (getting bigger/smaller), curious if this is the same with Reta?
Click to expand...
Reta isn't going to directly burn fat, so no, if all other variables remain the same, you won't experience a rebound effect.

Reta indirectly helps with fat loss through improving insulin sensitivity and suppressing appetite.

If using it at a high dose it's probably wise to taper off it so you don't experience a sudden rebound in appetite. At lower doses I don't see any reason to taper it down.
 
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