Ok bloodwork nerds....help me out

You may want research Alparisan, and Mulvalaplin. I read about Pelacarsen - believe all three are in phase 3 trials but suspect you may know someone who could procure these for you. It could be 6 months to 2 years before they make it to market as a prescription, or they may never make it depending on the results.

Was your test mg/dl or nmol/l readings?

Just because a doctor can't prescribe a medication is a ridiculous reason not to test for something that can indicate a severe risk of heart disease/stroke. There is a ton you can do to thin your blood via over the counter medication, quality supplements - but you know this already. If I had a LpA number that high - I would be on high doses of Carleson's cod liver oil and a low dose aspirin every few days at minimum, among other supplements to help prevent any clotting.
AI will tell you a statin is a good idea, but unless I had really fucked up lipids, I would not take one. I understand the logic behind it. A family member had a heart attack - female (SCAD - no reasons 110 lbs, no pill, not a smoker, eats well, exercises) and the doctor wanted to treat it like a normal heart attach with the play book with included a statin. Her liver enzymes went through the roof and felt like shit and was having kidney damage. She is now taking Carleson's cod liver oil / Nigella Sativa and 15 years later is doing great. SCAD is not like a normal heart attach. Anyway, if it isn't obvious I am not a fan of Statins, if I wanted to treat my cholesterol - I would pick another medication. If you look up alternatives - they refer to specific foods and healthy fats and dietary changes but I am a hippy.
I turn to Naturopathic remedies when the medical industry can't patent something yet, or don't have a name they can write on a piece of paper to help you - it is ridiculous.
If you are morbidly obese or vastly underweight with no obvious medical cause - no blood test is needed, but most doctors will send you to a nutritionist or explain the risks they run by having an unhealthy weight.
I looked back at all my blood tests and this has never been tested by my doc, but heart attacks/strokes don't run into my family, but thanks for the info @biguglynewf - I will be asking my doctor to check it. He won't say no - he is affable and you can walk him towards anything you want if there is logic behind it.

Hope these meds pass into the script stage soon. Best of luck.
 
Seeing some information suggesting niaspan and Coq10 coupled with a statin shows promise in lowering LpA by 30%.

Still a bad number assuming what ive read....but a great step in tge right direction

I'll report back after speaking to the doc who ordered the test.

I didn't have hormones tested in this last round of bloods....so I don't know what those numbers are. Hemoglobin and crit were high normal....expected there or actually higher since I was that long off some test.
 
gondar1 said:
In a sensible world if they were to do tests for things they don't have a treatment for yet as the number of positives pile up it would direct more resources towards figuring out a treatment for said ailment.
Click to expand...

This is my thinking. Pushing knowledge, pushes progress.

Look here at this board. Folks that generally know much more about such matters than the general public.

Yet not many so far that knows a lot on the subject.....

What if ( and this is done the rabbit hole) these nu.bers are, in fact, much more concerning health wise than typically lipid numbers?

What if there was more push to get this managed? Would there be less cv events? Especially those mysterious ones that seem to be reported as baffling? Are they?

Again, knowledge is power.....but I understand what sirbate is saying too....why get people crazy over things that can't be controlled?

But we do that in many other ways anyways.....so are docs just saving people and public concern?

Or are they hiding truths?

Interesting topic isn't it? Potential for far reaching applications as well.
 
biguglynewf said:
Interesting update.

My old doc called this morning about the bloodwork and was a little hot I saw someone else.

We got him calmed down. Lol. Seemed more concerned about being cut out rather than my health truly.....part of tge reason for the change....but that's another story.

I asked him about the ApoB and LpA numbers, what they meant and why he had never did the tests before.

His answer was this....

He only would ask for ApoB if I had significant family history with heart and stroke issues and my LDL numbers were bad.

My response was...well both of my grandfathers died in their early 60s from heart disease and I've had bad lipid numbers before.

Him - no real answer for not doing it, but he did note the number was in good order on this test. I knew that, I can read surprisingly.....but I digress...

He then went on to tell my that the college of medicine along with the ontario doctors association and family medicine has recently recommended that LpA not be tested for.

Why you may ask? I did....wait for it....

His explanation was this.....

Although that it has been proven that this is a significant health marker, possibly more so than LDL numbers, Ratio and ApoB.....there is no easy recognized treatment that has been approved in humans so its better not to test for it....since there isn't really a treatment.

Now, I understand the layers there....and even can apply a small amount of logic to his reasoning.....

But how backwards and fundamentally fucktarded is that thinking? Proof that it's significantly worse that high LDL, and LDL particles in the blood to form blockages....but let's not do anything about it. Yes...I understand that if there are no approved treatments, it creates panic over an issue they have no path to treat....but it seems short sighted and ridiculous. Especially when you think of the burden cardiovascular disease has on the Healthcare system.....but hey....we can fast track mRNA vaccines that don't do much, if anything, for a bad flu that really only kills already really sick people....but this? No.... let's not push this?

So...back to relevance in my situation....

Doc...ive done aone reading that speaks about doing a CAC scan now as having these numbers would seem to indicate that although we cant treat the LpA production, we could look to better determine if this shit is causing problematic blockages? That would be prudant would it not?

him - no, i dont see a reason for that at this time as your typical lipid numbers are good.

me.....hmmmmmm.

tell me, what am i missing from my layperson's understanding here? If this LpA atuff can actually be worse than high LDL and ApoB, could i not have blockages despure those numbers being well wirhin range?

him - im not sure if tgat would be the case.

Me - thanks for your time.

So noving forward....it will be interesting to see the position of tge new doc which ordered the test. One would think that their position/philosophy on the matter may be significantly different....since they ordered the test.

we shall see.

 
Obviously my bias is showing here...but hopefully you all can sense the message.

So with that....again.... fuck the establishment....

Hey China....since you're still on lockdown with aas production, can you start putting out some Pelacarsen, Olpasiran or Lepodisiran. I'll buy some! Lol!

Some other info if anyone is interested.

Just the abstract here:


Other niblets....

consultqd.clevelandclinic.org

Lipoprotein(a): Progress on One of the Last Untreatable Frontiers of Cardiovascular Risk

Promising new therapies for this important risk factor are far along in clinical testing. Wider measurement of Lp(a) levels is needed now.
consultqd.clevelandclinic.org consultqd.clevelandclinic.org


www.clinicaltrialsarena.com

Eli Lilly’s lepodisiran cuts lipoprotein(a) by 93.9% in Phase II trial

The Phase II study found that lepodisiran significantly reduced levels of genetically inherited cardiovascular risk factor.
www.clinicaltrialsarena.com www.clinicaltrialsarena.com
Click to expand...

Fundamentally it comes down to paternalistic medicine.

While their own charter dictates the requirement for informed consent, in practice it rarely if ever happens.

For example, they added tests you didn't know of. Therefore you were not informed, and did not consent.
That's a direct violation in itself.

They are still stuck in a Dr knows best paradigm, yet they are always 20 years behind.

And that 20 year gap becomes exponentially greater as we move faster with big data.
 
gondar1 said:
In a sensible world if they were to do tests for things they don't have a treatment for yet as the number of positives pile up it would direct more resources towards figuring out a treatment for said ailment.
Click to expand...

biguglynewf said:
This is my thinking. Pushing knowledge, pushes progress.

Look here at this board. Folks that generally know much more about such matters than the general public.

Yet not many so far that knows a lot on the subject.....

What if ( and this is done the rabbit hole) these nu.bers are, in fact, much more concerning health wise than typically lipid numbers?

What if there was more push to get this managed? Would there be less cv events? Especially those mysterious ones that seem to be reported as baffling? Are they?

Again, knowledge is power.....but I understand what sirbate is saying too....why get people crazy over things that can't be controlled?

But we do that in many other ways anyways.....so are docs just saving people and public concern?

Or are they hiding truths?

Interesting topic isn't it? Potential for far reaching applications as well.
Click to expand...


This is predicated on a belief that Drs do systemic thinking,
I had always assumed they did until relatively recently, but they don't. Everything is in siloed, single causation response/ pattern recognition.
Canadian guidelines do recommend that you get tested at least once to determine your overall risk profile, so your original Dr. has no excuses.


And yes it would be a great source of data for researchers to access for correlation hypothesis. And we now have the ability to crunch big data to find those statistically and clinically significant intersections.
That's the horse before the cart though,
And medicine since the 50s has been of the cart first. Hey we have a cool new molecule, let's see what it does and if we can make money off it. Run studies.
Beat placebo. Become standard of care. Profit.
 
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If you want the deep dive on LP(a) Peter Attia is good. Although I disagree with his conclusions.

Fast and still accurate, Nick Norwitz is good. Harvard medicine + Oxford PhD

My favorite is Dave Feldman,
He's an engineer not a DR, and speaks my language.


30min video by Norwitch that covers a lot, including possible interventions.
His absolute vs relative risk comparison should assuage your concerns.




Edit:
Looks like Nick has a new video out last month on LP(a)

Covers a new 2025 study,

TLDR...
If you're not fat, LP(a) shows no increased risk.

 
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biguglynewf said:
Seeing some information suggesting niaspan and Coq10 coupled with a statin shows promise in lowering LpA by 30%.

Still a bad number assuming what ive read....but a great step in tge right direction

I'll report back after speaking to the doc who ordered the test.

I didn't have hormones tested in this last round of bloods....so I don't know what those numbers are. Hemoglobin and crit were high normal....expected there or actually higher since I was that long off some test.
Click to expand...


Coq10 is one of those supplements I think is a no brainer for everyone to take once you hit middle age.
 
biguglynewf said:
I recently had some blood work done by a new practice we are transitioning to.

The NP that I met with sent me for baseline blood work and added a few extra things that I have never had checked before.

No true surprises....except one that sounds pretty ugly. Everything else was as expected and actually extremely great overall.

Liver values, lipids kidney function all in good order.

Here's the hook though.

It appears I have never had LpA tested before. It appears to be shockingly high. 281.

Triglycerides, ldl, hdl, ratio, ApoB - all excellent.

This seems to demonstrate terrible genes and there is little that can be done to improve these numbers as high LpA numbers coupled with good numbers otherwise leads to bad genes which makes my liver over produce this particle that sounds to be far worse than ldl for heart disease and stroke issues.

There are apparently a few drugs in trial that are showing promise but none have received fda approval. There is a process similar to dialysis that is apparently fda approved where these particles can be filtered from you blood.

So.....

What do you folks know about this apparent condition that I currently can do fuck all about other than keep other risk factors at bay? I do see niacin/q10 etc are suggested. However little to nothing else.

Not on anything aas wise, but not too long off 500mg/test cyp. 3-4 weeks. Haven't seen anything showing exo test would inflate this number, and all other lipids were well within reference ranges.

And how ugly is that number? It appears from my down the rabbit hole reading today....it ain't good!

If I croak before many responses are posted....fuck everyone...cause I'm going out miserably...lol!

Thanks for the ponders for those that share thoughts or feed me info.
Click to expand...
The key thing: Lp(a) is mostly genetic.

Diet and exercise barely move it.
 
Z155 said:
Sorry I wasn't done typing yet and hit reply.

PCSK9 inhibitors seem to be the only widely available option thats aproved
Click to expand...
Whoa fuck.... wanna loan me the 7.5k/yr?

Lol! It would appear my number is horrible, however I'm guessing I wouldn't qualify for provincial coverage.

Thanks man. Good discussion piece for the add...I had assumed that those inhibitors were the drugs still in trials (I think bigbear brought them up in one of his posts).

Glad you posted this and I checked them as the are different things.

Thanks everyone so far. I really appreciate so many chiming in.....but I couldn't resist kicking you in the balls before! Lol!
 
A
biguglynewf said:
Whoa fuck.... wanna loan me the 7.5k/yr?

Lol! It would appear my number is horrible, however I'm guessing I wouldn't qualify for provincial coverage.

Thanks man. Good discussion piece for the add...I had assumed that those inhibitors were the drugs still in trials (I think bigbear brought them up in one of his posts).

Glad you posted this and I checked them as the are different things.

Thanks everyone so far. I really appreciate so many chiming in.....but I couldn't resist kicking you in the balls before! Lol!
Click to expand...
As usual I'm trying to do too many things at one time...

Couple things to try

1- special authorization request from Dr and or pharmacy (a way to get covered for items typically not covered)

2 - Use Manufacturer or Patient Support Programs (some offer decent rebates)
 
Heraclitus said:
If you want the deep dive on LP(a) Peter Attia is good. Although I disagree with his conclusions.

Fast and still accurate, Nick Norwitz is good. Harvard medicine + Oxford PhD

My favorite is Dave Feldman,
He's an engineer not a DR, and speaks my language.


30min video by Norwitch that covers a lot, including possible interventions.
His absolute vs relative risk comparison should assuage your concerns.




Edit:
Looks like Nick has a new video out last month on LP(a)

Covers a new 2025 study,

TLDR...
If you're not fat, LP(a) shows no increased risk.

Click to expand...

So fat people are at higher risk for CVD, LOL. Who woulda thunk….
 
animal-inside said:
Coq10 is one of those supplements I think is a no brainer for everyone to take once you hit middle age.
Click to expand...
I was in my late 20’s and had a cyst in my scrotum. Had it for like 2 years, doc said don’t worry it’s harmless, might go away, might not, if it gets bigger and bothers me they can remove it.

Well I had been doing some reading and coenzyme q10 was supposed to shrink tumours, cysts and so on, thought what the hell, got nothing to lose, let’s try it.

2 months after starting to take it, the cyst was gone. Was I coincidence? Maybe, but 2 years and only change was co enzyme.

Been taking it ever since.
 
So from new doc today......

CAC screen and go from there depending on what we see.

There are some off lable possibilities that can apparently help to lower LPa if needed or possible referrals perhaps.

As others advised, best to focus on the things we have under control....which also seems to be the messaging in the videos above.

Doc advised that there's a real possibility everything is fine and scoring my levels against some risk factor calculation - my risk is moderate-ish..... but more information is always better. At least theres a plan past....well...lets wait and see what happens.

This doc's overall philosophy seems drastically more proactive and wants to act...not wait. I like that.
 
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