Low Dose Cialis AI effects

R

resilient1

Well-known member
Trusted Member
Can anyone else confirm that they've had AI or observed low E2 symptoms when taking ~5mg of Cialis daily? It's the only variable I can account for, but until I get bloodwork I won't know for certain. I will first cut out the cialis and see if that makes a difference. The effect wasn't immediate, however, after about a couple weeks I started exhibiting low E2 symptoms on what had been a stable trt dose.

If cessation of Cialis doesn't affect it, then perhaps my shbg has increased? All I know is I've been anxious, sweating/damp throughout the night, having trouble getting decent sleep, and edgy. Cialis has been shown to produce some mild AI effects.
 
Just on TRT? Get some blood work. Couple factors- DHT has been known to be anti estrogenic in nature so you may have more testosterone converting to DHT and having low estradiol. I seriously doubt cialis has a thing to do with it. I have never read anything of that and the actual drug profile I doubt would produce those effects
 
there are a ton of dudes on 5mg daily Cialis for years, .. can't see it being this if it's not a documented side already.
 
aGuyFromWinnipeg said:
there are a ton of dudes on 5mg daily Cialis for years, .. can't see it being this if it's not a documented side already.
Click to expand...
pubmed.ncbi.nlm.nih.gov

Testosterone:estradiol ratio changes associated with long-term tadalafil administration: a pilot study - PubMed

Sustained improvement in sexual function after 12 months of tadalafil administration is associated with increased T:E ratio mainly related to reduction of E levels. We hypothesize that androgen-estrogen cross-talk and possible inhibition of aromatase activity during chronic exposure to tadalafil...
pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov

This is a study that was posted in another thread. The more likely reason is my shbg increased/ what I had been taking is just not quite enough. Slept alright last night, so we'll see how it is going forward.

I agree with you, though. If this was a thing I would have expected many more guys on trt having a similar experience.

@A.B Not on anything else, just trt.
 
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