Can you show me some source for this please - "They have been proven to be SYNERGISTIC in nature."Okay, I'll just give you the benefit of the doubt that you have some science and research behind your statement.
Thus I will show you the research behind my opinion
First Front loading
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This CLEARLY states
half life of clomid is 6 days.
THERFORE.
Front loading, will not make you FEEL any different from just your usual DAILY dose
The SAME applies with Nolvadex.
You will reach full saturation at day 1 as opposed to day 4..
Making the PCT "hocking to your HPTA axis.
Therefor the frontload is
1)
Non Harmful in terms of quantities
2)
Does a better job of restart.
3) Allowsthe compound to build up quickly and shock the Hypothalamus and pituitary.
You'll see I used the term shock, a lot there
Here is why.
(I got this information from @Old from Meso, who is paraphrasing from GRAYS ANATOMY)
As such
- The hypothalamus is part of the brain ... it is brain tissue (neurons).
- Neurons require continual stimulation (receiving pulses from other axions to their dendrites) or they will die.
- The brain THRIVES on CHANGE.
- The greater (sudden+magnitude) the change the greater the brain reacts.
- Regulatory systems monitor changes and respond accordingly
- When part of the hypothalamus is nearly shutdown, it adapts to functioning in that new range of continually elevated E2 and/or androgens.
- If one waits for natural production to restore without intervention, it can take months, or years, or never truly never returns to healthy ranges. Gradual feedback signals result in gradual, lackluster responses.
- When the hypothalamus receives a sudden, dramatic change in E2 and/or T, it adapts more strongly. IMO that is why front-loading the first day of SERM(s) is important.
- So perhaps the sudden change with triptorelin (as seen in Figure 1) incited the hypothalamus to respond more quickly to low E2 and T
it is VITALLY imports t to front load and NON Harmfull to do so.
Moving on to the nolvadex Clomid combination
They have been proven to be SYNERGISTIC in nature.
with a much better ability to ..
1)Shock the hypothalamus specifically
2)Assist with pituitary restart.
This Pct I laid out, was NOT MY IDEA
It was created by a team of 4 AAS using and research doctors.
One of which is the Legendary Michael scally.
(Whom the protocol is named after)
With decades of research a d knowledge behind them.
I'm sorry @ABMonkey but basic pharmacokinetics disagrees and Every research study disagreeswith your opinion.
YOU may have a bullet proof HPTA ... but not everyone does.
If he gets to HIGHER than pre cycle levels...
Them sure
Switch to a Nolva only cycle.
Until then, an opinion is NO substitute for research and teams of MDs
Some reading here offering a different view....(backed up with medlit)
"Controversy
Aside from the high Clomid and HCG dosages, it should be noted that there is some controversy on whether using two SERMs at once is beneficial or not.
This is one of the explanations that Dr. Scally has given:
Clomid acts as an estrogen, rather than an anti-estrogen, by sensitizing pituitary cells to the action of GnRH. Although tamoxifen is almost as effective as Clomid in binding to pituitary estrogen receptors, tamoxifen has little or no estrogenic activity in terms of its ability to enhance the GnRH-stimulated release of LH. The estrogenic action of Clomid at the pituitary represents a unique feature of this compound and that tamoxifen may be devoid of estrogenic activity at the pituitary level.
Some strongly disagree with Dr. Scally's reasoning behind the use of clomid. What he is describing here is believed to be "estrogen priming," the concept that estrogen makes the pituitary more sensitive to GnRH from the hypothalamus, so that more LH is released for a given GnRH stimulus. This is well known to occur in females leading up to ovulation. Unlike females, however, men don't have a preovulatory period or spikes in LH. The research is fairly clear that estrogen priming does not occur in males. For starters, take a look at an authoritative reference work like Grossman's Clinical Endocrinology, which states (pg. 99):
Progesterone, acting synergistically with oestrogens, exerts negative feedback on the hypothalamus during the luteal phase, thus limiting GnRH pulsatility and slowing LH pulse frequency. The mechanism of positive oestrogen feedback at the time of the LH surge has been much debated. There is now evidence that enhancement of both hypothalamic GnRH pulse generator activity and pituitary responsiveness to GnRH are involved. All species so far studied have shown an increased 'self-priming' effect of GnRH on the pituitary during the preovulatory period... In males, the situation is more straightforward. Since LH surges do not occur, only negative feedback effects are relevant. testosterone (and its active metabolite dihydrotestosterone, DHT) exerts major suppressive effects on both LH and FSH secretion, largely by inhibiting the GnRH pulse frequency generator, but possibly also by direct pituitary actions. Oestrogens in the male reduce pituitary responsiveness to GnRH.
That states clearly that there is no priming in males, only negative feedback. The last emboldened sentence in this quote directly contradicts Dr. Scally's quote above. If clomid were to produce estrogenic action in the pituitary, it would only serve to inhibit LH secretion.
Grossman's statement is corroborated by the more recent research on the specific effects of androgens and estrogen on the pituitary and hypothalamus of healthy men. Here, it was shown that estrogenic action at the pituitary has an inhibitory effect on LH output. In other words, estrogen decreases pituitary sensitivity to GnRH. Estrogen does not produce positive feedback as seen in estrogen priming in females. The paper stated in its conclusion that: "These data confirm previous work from our group which ... showed [estrogen] has both hypothalamic and pituitary sites of negative feedback in the male." In fact, "negative feedback at the pituitary requires aromatization," as testosterone itself doesn't produce negative feedback at the pituitary.
This older paper had a very interesting finding:
The positive estrogen feedback was found to be a relatively sex-specific reaction of the hypothalamo-hypophyseal system in rats as well as in human beings. It is dependent--most of all--on the estrogen convertible androgen level during sexual brain differentiation, but also on an estrogen priming effect in adulthood. The lower the estrogen convertible androgen or primary estrogen level during brain differentiation, the higher is the evocability of a positive estrogen action on LH secretion in later life. In clinical studies, we were able to induce a positive estrogen feedback on LH secretion in most intact homosexual men in clear-cut contrast to intact hetero- or bisexual men. These findings were strongly confirmed by Gladue and associates.
In other words, estrogen levels during brain development are responsible for the sex-specific differences in gonadotrophin secretion and estrogen feedback at the pituitary. The important point of this research is that males (with the exception of homosexuals) were not found to have any positive feedback from estrogen. Those results that were "strongly confirmed."
Finally, there's this research (that was referenced above), which couldn't have been any more relevant. It directly examined the effects of nolva and clomid on the pituitary of human males. They infused the men with 100 mcg of GnRH and then measured LH output from the pituitary. The men taking nolvadex at 20mg/day had a significantly increased LH response to GnRH. In contrast, the men taking clomid had reduced LH output, a decreased sensitivity to GnRH. The researchers stated that "a role of the intrinsic estrogenic activity of Clomid which is practically absent in Tamoxifen seems the most probable explanation."
Full thread/source here: https://www.canadianbrawn.com/threads/post-cycle-therapy.3519/
Literally thousands of folk have had great success with using nolvadex only and experienced zero sides. Just ask the guys over on R/steroids (they have a membership base of almost 100k).
For a simple cycle like this, I would not include clomid for reasons mentioned in my previous post.