Anti-Aging supplements ( NR / NMN)

Rocky

Well-known member
Trusted Member
I'm getting old and I can start feeling things just aren't how they used to be, mental clarity, energy, drive, tried some hormone manipulation but nothing really has done it for me. I'm not too old numerically but I am guessing I aged a lot more from my earlier years.

Starting to dabble into anti-aging supplements and wanted to see if anyone was taking some as well.

I'll be trying out NR / NMN to boost intracellular NAD levels and resveratrol

Seems like blood flow may have a lot to do with it as well which might be a double edged sword in my case with tumours, might try low dose Cialis, and I'll have to start exercising again.
 
I'm getting old and I can start feeling things just aren't how they used to be, mental clarity, energy, drive, tried some hormone manipulation but nothing really has done it for me. I'm not too old numerically but I am guessing I aged a lot more from my earlier years.

Starting to dabble into anti-aging supplements and wanted to see if anyone was taking some as well.

I'll be trying out NR / NMN to boost intracellular NAD levels and resveratrol

Seems like blood flow may have a lot to do with it as well which might be a double edged sword in my case with tumours, might try low dose Cialis, and I'll have to start exercising again.
I haven't yet but I'm interested in these too. Let us know how it goes. I'm sure it's more than beneficial.
 
I haven't yet but I'm interested in these too. Let us know how it goes. I'm sure it's more than beneficial.
Seems like NR / NMN are similar in effect but takes weeks, resveratrol I have used before and it worked really well. It was the only thing I ever took that got my liver enzymes back down to extremely low levels, I tried all the typical liver supplements, nothing even budged my liver enzymes
 
Seems like NR / NMN are similar in effect but takes weeks, resveratrol I have used before and it worked really well. It was the only thing I ever took that got my liver enzymes back down to extremely low levels, I tried all the typical liver supplements, nothing even budged my liver enzymes
good to know, thanks for the heads up....any particular brand you recommend?
 
This is hard to put into a paragraph and not make members skip over it but there is so much info on this topic.

Opinion only but we age internally which shows on the outside. Glutathione is the mother of all antioxidants and supplements that increase this antioxidant are a bonus: NAC / SAME for example are good ones. Free radicals age us / antioxidants render these inert and as such, diets and supplements knows to render them useless are going to be a bonus.

There are endless antioxidants and so many to choose from it is hard to know which is best. I love ginger, nigella sativa, curcumin, Crocin, etc. Resveratrol is studied and is in most anti-aging forums but there is interesting info that follows the supplement. I am not stating this for fact but I have read papers that indicate people are healthier taking resveratrol but they lose a few years of live - makes no sense to me and I am regurgitating what I read. This is a forum on anti-aging which I take a lot with a grain of salt and make sure I do my own research:
https://www.longecity.org/forum/forum/6-supplements/

If you focus on high quality antioxidants and anti-inflammatory products - you are doubling down and doing yourself a favour. Think of ginger and curcumin as an example - make sure you get enough piperine if you take curcumin.
Collagen both internally and externally can make you feel better (pain) and look better but oral collagen is contraversial. I am repeating myself but look up the building blocks of collagen like L-Proline, L-Lysine, Arginine, L-Glycine. I find the building blocks of collagen work better and I take them for my joints.

If you are willing to take peptides - epithalon is supposed to elongate your telomeres - they shrink as we age. 2 mg for 10 days is what I take twice a year. 2 bottles of 10 mg's is a 'run'. The link I attached covers this as well.
I don't notice a lot from copper peptide but if the info is accurate, it is a great supplement. I use to take too much and reduced it down to 2 mg per day, for 30 - 60 days. I buy the 20 mg/ml (I think 10 ML vial) which is 100 days worth. Would I be worried about taking it for 60-90 days, no but take zinc if you take the peptide. A quick google search will explain why. Many take 25 mg of zinc a day, I eat foods high in zinc but still take 10 mg a day.

I have a book on anti-aging and can look up what it says. It is old - probably 15 years and is called Prescriptions for Natural Cures and I believe there is a section on aging - I will look up if there is any additional info.

A friend on this forum pointed out some contradictions with ginger and aspirin so please go to reputable medical sites and read - I wouldn't take both at the same time.
I state this because aspirin truly is a magical little medication that does have negative side effects too. We are all adults but info is power so read up on the negatives and you can decide for yourself.
If I was worried - I would take ginger (incredibly powerful anti-inflammatory, protects organs, is full of antioxidants, etc.)

Aspirin is studies more because it is a drug sold by multiple companies - there are endless studies on it's ability to prevent a second heart attack and some evidence it can prevent a first. It has anti-platelet activity hence great for clots. You don't have to take it ED. There is a large 20 year study somewhere I posted with 1000's of doctors who took 325 mg every 4 days over 20 years and the results indicate less health issues related to the platelet issues we can have. Low dose enteric coated aspirin is meant to be taken ED but can be taken EOD. I swap - sometimes aspirin and sometimes ginger. You may find this interesting: https://www.researchgate.net/public...lementation_as_a_Means_to_Extending_Life_Span

If inflammation is our enemy and cancer is of course too as are clots - how can aspirin not be good for you? The answer is the danger for ulcers, bleeding, and worst case scenario a perforation and septis. Albeit the odds of the latter is low - to think it can't happen is naive. Everything in moderation!

Kind of a ridiculous statement but a varied diet with food that meet your caloric needs, loaded in healthy fats, and clean (I try to get pesticide free - free range meat). Almonds, olive oil, the neighbour up the road has free range chickens and they live off the land and their eggs and meat is so much better than what you get a grocery store.

Like I said I could keep writing and put people to sleep with peptides, having a good hormonal balance, antioxidants, etc. but it is too long. If you wish to discuss further, we can go to PM or write here but I don't want to members to sleep.

Last comment to keep in mind - stress is a killer period. Learning to control stress is vital to a happy/healthy life. People who are happier and healthy 'in a perfect world' should live longer. Stress hormones are bad for the body. Albeit nothing like a prescription drug, if I am stressed from work, life, etc. I take a product that has 4 adaptogens that help control stress hormones. I deal well with stress but I have used it multiple times when life throws shit in your face. I like Natural Factors Serenity Formula. https://naturalfactors.com/products...UsxtWgbK1UYZVfbhyWGN7Dc5ew0vHRnCv84NxmvC0AkPK
that is the product but there are lots of other good ones.
 
This is hard to put into a paragraph and not make members skip over it but there is so much info on this topic.

Opinion only but we age internally which shows on the outside. Glutathione is the mother of all antioxidants and supplements that increase this antioxidant are a bonus: NAC / SAME for example are good ones. Free radicals age us / antioxidants render these inert and as such, diets and supplements knows to render them useless are going to be a bonus.

There are endless antioxidants and so many to choose from it is hard to know which is best. I love ginger, nigella sativa, curcumin, Crocin, etc. Resveratrol is studied and is in most anti-aging forums but there is interesting info that follows the supplement. I am not stating this for fact but I have read papers that indicate people are healthier taking resveratrol but they lose a few years of live - makes no sense to me and I am regurgitating what I read. This is a forum on anti-aging which I take a lot with a grain of salt and make sure I do my own research:
https://www.longecity.org/forum/forum/6-supplements/

If you focus on high quality antioxidants and anti-inflammatory products - you are doubling down and doing yourself a favour. Think of ginger and curcumin as an example - make sure you get enough piperine if you take curcumin.
Collagen both internally and externally can make you feel better (pain) and look better but oral collagen is contraversial. I am repeating myself but look up the building blocks of collagen like L-Proline, L-Lysine, Arginine, L-Glycine. I find the building blocks of collagen work better and I take them for my joints.

If you are willing to take peptides - epithalon is supposed to elongate your telomeres - they shrink as we age. 2 mg for 10 days is what I take twice a year. 2 bottles of 10 mg's is a 'run'. The link I attached covers this as well.
I don't notice a lot from copper peptide but if the info is accurate, it is a great supplement. I use to take too much and reduced it down to 2 mg per day, for 30 - 60 days. I buy the 20 mg/ml (I think 10 ML vial) which is 100 days worth. Would I be worried about taking it for 60-90 days, no but take zinc if you take the peptide. A quick google search will explain why. Many take 25 mg of zinc a day, I eat foods high in zinc but still take 10 mg a day.

I have a book on anti-aging and can look up what it says. It is old - probably 15 years and is called Prescriptions for Natural Cures and I believe there is a section on aging - I will look up if there is any additional info.

A friend on this forum pointed out some contradictions with ginger and aspirin so please go to reputable medical sites and read - I wouldn't take both at the same time.
I state this because aspirin truly is a magical little medication that does have negative side effects too. We are all adults but info is power so read up on the negatives and you can decide for yourself.
If I was worried - I would take ginger (incredibly powerful anti-inflammatory, protects organs, is full of antioxidants, etc.)

Aspirin is studies more because it is a drug sold by multiple companies - there are endless studies on it's ability to prevent a second heart attack and some evidence it can prevent a first. It has anti-platelet activity hence great for clots. You don't have to take it ED. There is a large 20 year study somewhere I posted with 1000's of doctors who took 325 mg every 4 days over 20 years and the results indicate less health issues related to the platelet issues we can have. Low dose enteric coated aspirin is meant to be taken ED but can be taken EOD. I swap - sometimes aspirin and sometimes ginger. You may find this interesting: https://www.researchgate.net/public...lementation_as_a_Means_to_Extending_Life_Span

If inflammation is our enemy and cancer is of course too as are clots - how can aspirin not be good for you? The answer is the danger for ulcers, bleeding, and worst case scenario a perforation and septis. Albeit the odds of the latter is low - to think it can't happen is naive. Everything in moderation!

Kind of a ridiculous statement but a varied diet with food that meet your caloric needs, loaded in healthy fats, and clean (I try to get pesticide free - free range meat). Almonds, olive oil, the neighbour up the road has free range chickens and they live off the land and their eggs and meat is so much better than what you get a grocery store.

Like I said I could keep writing and put people to sleep with peptides, having a good hormonal balance, antioxidants, etc. but it is too long. If you wish to discuss further, we can go to PM or write here but I don't want to members to sleep.

Last comment to keep in mind - stress is a killer period. Learning to control stress is vital to a happy/healthy life. People who are happier and healthy 'in a perfect world' should live longer. Stress hormones are bad for the body. Albeit nothing like a prescription drug, if I am stressed from work, life, etc. I take a product that has 4 adaptogens that help control stress hormones. I deal well with stress but I have used it multiple times when life throws shit in your face. I like Natural Factors Serenity Formula. https://naturalfactors.com/products...UsxtWgbK1UYZVfbhyWGN7Dc5ew0vHRnCv84NxmvC0AkPK
that is the product but there are lots of other good ones.
Yes, there is a lot of conflicting evidence on whether healthier short term leads to longer lifespan, I believe this was seen with overuse or overconsumption of antioxidants.

David Sinclair theorized that it may be that the body is being over protected to where the natural defences from oxidative stress is negated, such that, you don’t receive the benefits of oxidative stress.

One would thing that oxidative stress is always bad, but the body requires some stress to cause a feedback loop or reaction to strengthen the body from stress’

this is a bit of a vague response as I’m in class but the main idea is that some stress is good for the body.
 
good to know, thanks for the heads up....any particular brand you recommend?
I haven’t done much research in this, I used to use a website which did 3rd party lab testing, but forgot the name. It was quite interesting actually, a lot of top brand name supplements had heavy metals or other containments.

If I find a good brand I will post and reasons why I think it’s a good brand. I typically use life extensions as a safe go to
 
David Sinclair also talks about using metformin, cholesterol meds and blood pressure meds for longevity, what's your thoughts on that? I think metformin is an interesting idea.
 
David Sinclair also talks about using metformin, cholesterol meds and blood pressure meds for longevity, what's your thoughts on that? I think metformin is an interesting idea.
Pretty sure he isn’t doing pushing metformin anymore and he was trying to patent NMN so he could make money off it and it wouldn’t be available over the counter. All these “experts” seem to have a financial interest in their recommendations.
 
Yes, there is a lot of conflicting evidence on whether healthier short term leads to longer lifespan, I believe this was seen with overuse or overconsumption of antioxidants.

David Sinclair theorized that it may be that the body is being over protected to where the natural defences from oxidative stress is negated, such that, you don’t receive the benefits of oxidative stress.

One would thing that oxidative stress is always bad, but the body requires some stress to cause a feedback loop or reaction to strengthen the body from stress’

this is a bit of a vague response as I’m in class but the main idea is that some stress is good for the body.
Well said, I agree some stress is good for the body and can help prevent specific cancers (odd to say that) and stress to some degree builds your immune system. I just don't know where the fine balance is. Too much chronic stress will deplete your body from it's ability to fend off 'invaders' whether bacterial, virus, or whatever and it is hard on the BP, organs, etc. but I do not disagree with you at all. It messes you up in the head which brings all kinds of other issues if it can't be controlled.
Interesting topic which would be good to dig into. I recall many moons ago my farming neighbour saying kids are getting sick today because they aren't out in the farm working, getting dirty, flexing their immune system and when something comes along - they get it. There is a lot of common sense to that statement.
 
David Sinclair also talks about using metformin, cholesterol meds and blood pressure meds for longevity, what's your thoughts on that? I think metformin is an interesting idea.
i have heard great things about low dose metformin in non-diabetics from my boss when i worked at the pharmacy.
 
i have heard great things about low dose metformin in non-diabetics from my boss when i worked at the pharmacy.
That's interesting, I am surprised pharmacists are catching onto that since its very speculative right now.

There is the fairly well known trial going on called TAME, it was due to them finding that those with diabetes taking metformin lived longer than those who didn't have diabetes.
The correlation didn't happen with other diabetic drugs and thought there was some mechanism within metformin. They are hypothesizing it's because metformin decreases mTOR, a reason why rapamycin is being hypothesized to increase lifespan as well.

I have a few bottles of metformin but I don't like taking it since it decreases energy levels for me.

Another interesting thing is, metformin is sold over the counter for a few dollars in a lot of countries (not Canada) so it's a really cheap, low risk, medication to take.
 
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