Colon cancer: Could aspirin help slow disease progression?
A study found that aspirin can activate protective genes to inhibit and slow the progression of colon cancer.
www.medicalnewstoday.com
Aspirin may help protect against colorectal cancer, study suggests
- Thread starter Bagua
- Start date
www.medicalnewstoday.com
Aspirin, albeit a NSAID and high dose may (or even low dose) cause ulcers and bleeding issues, the benefits from low dose aspirin ED or EOD are remarkable if the studies are accurate. I will take 81 mg a day of enteric coated until I am told I can't due to it causing a medical issue.
Interesting, I remember reading that Dr. David Sinclair, professor/scientist at Harvard university researching lifespan/anti-aging techniques also takes aspirin because of the research done on it and it's ability to prevent cancer as wellColon cancer: Could aspirin help slow disease progression?
A study found that aspirin can activate protective genes to inhibit and slow the progression of colon cancer.
i may consider taking some daily low dose
Aspirin and cancer treatment: systematic reviews and meta-analyses of evidence: for and against ,
British Journal of Cancer, November 2023
A comprehensive review on aspirin risks/benefits.
TLDR
Bleeding risks are overstated,
Aspirin use highly correlates with prevention of many types of cancer and metastases.
Horror Cock
Active member
One who made a billion selling a lab that was abandoned... now uses botox but not eager to remove his man boobs...
Anyway aspirin is anti inflammatory. Beneficial and all just don't take it around your workouts.
It's more the brain hemorages I'd be worried about
Intracranial Hemorrhage With Low-Dose Aspirin in People Without Symptomatic Cardiovascular Disease
This systematic review and meta-analysis assesses the risk of intracranial hemorrhage associated with low-dose aspirin among individuals without symptomatic cardiovascular disease.
jamanetwork.com
This bleeding risk was also discussed in the review. Hypertension being a coincident contributor to risk.It's more the brain hemorages I'd be worried about
Intracranial Hemorrhage With Low-Dose Aspirin in People Without Symptomatic Cardiovascular Disease
This systematic review and meta-analysis assesses the risk of intracranial hemorrhage associated with low-dose aspirin among individuals without symptomatic cardiovascular disease.
Unlike a gastrointestinal bleed, the consequences of a cerebral bleed, whether or not fatal, can be of a severity comparable to a cancer or a myocardial infarct in a risk/benefit evaluation. Estimates of additional risk in patients on aspirin are around one or two events per ten thousand (10,000) subject-years. The major factor in cerebral bleeding however is hypertension, and in an RCT of aspirin based on more than 18,000 hypertensive patients—all of whom were receiving ‘optimal’ antihypertensive treatment—there were no additional cerebral bleeds in patients randomised to aspirin.
That's good, the study I posted was in patients without symptomatic cvd. I wonder if hypertension would be included or not. I didn't actually read it entirely some of the raw data is hard to understand
There is a recent study mentioning the anti Cancer properties of low dose aspirin, some ppl had tumors encircled preventing the cancer to metastasize in lungs, and other areas, very interesting!
www.ncbi.nlm.nih.gov
Aspirin and cancer: biological mechanisms and clinical outcomes
Evidence on aspirin and cancer comes from two main sources: (1) the effect of aspirin upon biological mechanisms in cancer, and (2) clinical studies of patients with cancer, some of whom take aspirin. A series of systematic literature searches identified ...
www.ncbi.nlm.nih.gov
Tell us more about David Sinclair selling an abandoned lab, I couldn't find anything by googling that, also I googled his net worth, and it just came up as 25 million.
I know he's unpopular for trying to patent NMN and stuff, and he's quite the self promoter but I haven't heard anything about fraud.
Horror Cock
Active member
All the major outlets, Reuters, Forbes, etc. https://duckduckgo.com/?q=GlaxoSmithKline+bought+sirtis+in+2008+for+$720+million&ia=web
Then he responded to question on twitter with "
" and blocked
I will admit I have 30 min to go through a slew of threads and didn't read this article yet. Is it stating aspirin increases hypertension? I am asking because multiple studies show low dose aspirin taken at night (not during the AM) has the opposite effect. I have read enough, weighing good vs. bad to take low dose aspirin at least 4-5 days a week. From my reading no drug is perfect or I haven't found one as some people's physiology will put them at risk for issues, but this is as close to a wonder drug as any I have read about for knocking down %'s of different causes of morbidity or serious issues. Just my opinion. One of my relative had to stop a stronger NSAID due to intestinal bleeding but due to clotting issues still is prescribed a low dose aspirin daily and he has no bleeding issues. It was prescribed by his GP and surgeon who removed did two of the surgeries to prevent the need for further.
No, they just stated that hypertension is the major risk factor in cerebral bleeding.
And that a study done on a cohort of hypertensives taking aspirin had no additional cerebral bleeding when their BP is under control.
The subtext here could be that those with uncontrolled high BP might have higher cerebral bleeding risk if they take aspirin. I'll look for the actual study to see if that was the case.
*******
Edit: found the study this study referred to, and it can't be determined as there was no control arm of untreated hypertensives.
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Results The search identified 13 randomized clinical trials of low-dose aspirin use for primary prevention, enrolling 134 446 patients. Pooling the results from the random-effects model showed that low-dose aspirin, compared with control, was associated with an increased risk of any intracranial bleeding (8 trials; relative risk, 1.37; 95% CI, 1.13-1.66; 2 additional intracranial hemorrhages in 1000 people), with potentially the greatest relative risk increase for subdural or extradural hemorrhage (4 trials; relative risk, 1.53; 95% CI, 1.08-2.18) and less for intracerebral hemorrhage and subarachnoid hemorrhage. Patient baseline features associated with heightened risk of intracerebral hemorrhage with low-dose aspirin, compared with control, were Asian race/ethnicity and low body mass index.
Conclusions and Relevance Among people without symptomatic cardiovascular disease, use of low-dose aspirin was associated with an overall increased risk of intracranial hemorrhage, and heightened risk of intracerebral hemorrhage for those of Asian race/ethnicity or people with a low body mass index.
All the major outlets, Reuters, Forbes, etc. https://duckduckgo.com/?q=GlaxoSmithKline+bought+sirtis+in+2008+for+$720+million&ia=web
Then he responded to question on twitter with "
GlaxoSmithKline wouldn't buy an abandoned lab for $720M, biotech is very rewarding if you are able to find something revolutionary, which is what he must have done to obtain a $720M cheque
Horror Cock
Active member
I should have worded it different.
The main project they bought was later abandoned because some people even died during resveratrol trials.
Also he didnt make a full billion all for himself as he wasn't the only owner of the lab.