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In the human body, IGF-1 is the most popularly known IGF hormone both medically and in performance based circles. However, it is not the only IGF hormone; in fact, there are six IGF related hormones. IGF-1-BP3, known as SomatoKine in synthetic form, developed by Insmed is the primary binding protein that mimics the actions of IGF-1. With BP3 added, it appears to provide the benefits of IGF-1 without the often negative hypoglycemia associated with the insulin like hormone.
In clinical studies, IGF-1-BP3 has been considered for treatment in diabetes, burn victims, those suffering from Growth Hormone Insensitivity Syndrome (GHIS) and osteoporosis. However, in recent years all studies involving osteoporosis and burn victims has been shelved and focus has primarily been placed on GHIS and diabetes.
IGF-1-BP3 Functions and Traits
IGF-1 is comprised of 70 amino acids and functions by supporting the enhancement of glucose, fatty acids and amino acids in the body. Because of its close relation to another hormone, insulin, IGF-1 can potentially lower blood sugar and promote fat gain if used improperly.
By activating the phosphatidylinositol 3-kinase (PI3K)-AKT, IGF-1 will increase muscle mass by increasing the number of cells within skeletal muscle. This will not only promote muscle growth but bone growth and strength, as well as potential organ growth.
IGF-1 also carries a close relationship with another powerful hormone in Human Growth Hormone (HGH). Both IGF-1 and HGH have the ability to increase protein synthesis as well as nitrogen retention in the muscle. Protein synthesis refers to the rate in which cells build proteins, the primary building block of muscle tissue. Increased rates in protein synthesis is imperative to both growth and muscle recovery. Nitrogen retention (muscle tissue is comprised of 16% nitrogen), when retention rates fall this can lead to a catabolic state. The reverse is a greater rate of retention, which leads to a stronger anabolic environment. Most importantly, as with HGH, IGF-1 will increase new muscle fibers.
Important note: IGF-1’s effects are dependent on the amount of protein provided to the body. Inadequate amounts of protein will render IGF-1 somewhat useless.
IGF-1 also plays an important role on healing and recovery, particularly when we consider the hormone’s effect on connective tissues. IGF-1 will enhance collagen synthesis, which results in stronger bones and muscles. IGF-1 will also promote cartilage repair and bone density.
IGF-1-BP3 provides all the effects of IGF-1; however, its benefit is a greater impact on direct action and a significant lessening effect in terms of hypoglycemia. The reason for the improvement in effect is in that IGF-1-BP3 is already bound to the binding protein (BP3), however, data is still somewhat limited in terms of how great this effect is over standard IGF-1.
In clinical studies, IGF-1-BP3 has been considered for treatment in diabetes, burn victims, those suffering from Growth Hormone Insensitivity Syndrome (GHIS) and osteoporosis. However, in recent years all studies involving osteoporosis and burn victims has been shelved and focus has primarily been placed on GHIS and diabetes.
IGF-1-BP3 Functions and Traits
IGF-1 is comprised of 70 amino acids and functions by supporting the enhancement of glucose, fatty acids and amino acids in the body. Because of its close relation to another hormone, insulin, IGF-1 can potentially lower blood sugar and promote fat gain if used improperly.
By activating the phosphatidylinositol 3-kinase (PI3K)-AKT, IGF-1 will increase muscle mass by increasing the number of cells within skeletal muscle. This will not only promote muscle growth but bone growth and strength, as well as potential organ growth.
IGF-1 also carries a close relationship with another powerful hormone in Human Growth Hormone (HGH). Both IGF-1 and HGH have the ability to increase protein synthesis as well as nitrogen retention in the muscle. Protein synthesis refers to the rate in which cells build proteins, the primary building block of muscle tissue. Increased rates in protein synthesis is imperative to both growth and muscle recovery. Nitrogen retention (muscle tissue is comprised of 16% nitrogen), when retention rates fall this can lead to a catabolic state. The reverse is a greater rate of retention, which leads to a stronger anabolic environment. Most importantly, as with HGH, IGF-1 will increase new muscle fibers.
Important note: IGF-1’s effects are dependent on the amount of protein provided to the body. Inadequate amounts of protein will render IGF-1 somewhat useless.
IGF-1 also plays an important role on healing and recovery, particularly when we consider the hormone’s effect on connective tissues. IGF-1 will enhance collagen synthesis, which results in stronger bones and muscles. IGF-1 will also promote cartilage repair and bone density.
IGF-1-BP3 provides all the effects of IGF-1; however, its benefit is a greater impact on direct action and a significant lessening effect in terms of hypoglycemia. The reason for the improvement in effect is in that IGF-1-BP3 is already bound to the binding protein (BP3), however, data is still somewhat limited in terms of how great this effect is over standard IGF-1.
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